1. The Spanish Biotech sector in figures
Juan Carlos Cortés
International Director
Centre for the Development of Industrial Technology
Ministry of Economy & Competitiveness
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 1 (07/02/2013)
Una manera de hacer Europa

2. The Spanish Biotech sector
• A young sector, 15 years old.
• Internationalization is part of its DNA.
• Success depends on the capacity to export.
• Crucial: joint projects and technology exchange
agreements.
Spain:
• Biotech industry growth in the last four years 350%
• A key player in R&D, spin-offs, research and
collaboration.
• Biotech: a key sector in the knowledge economy
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 2 (07/02/2013)
Una manera de hacer Europa

3. The Spanish Biotech sector now
Source: Genoma España/ASEBIO
• Nº enterprises: 1.715 (617 EB+1.098 EIB)
• Nº personnel employed EB1+EIB2: 163.526
• Estimated turnover EB (2010): 60.122 MM€
• Internal expenditures in R&D: 568.280 M€ (11,2% increase from
2009)
• Enterprises related to human health: 67%
• Enterprises related to agro-food: 23%
• Enterprises related to industrial processing: 10%
1EB: biotechology enterprise
2EIB:industrial commercial or services’ enterprise, with interests, develpments and products in
biotechnology
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 3 (07/02/2013)
Una manera de hacer Europa

4. Contribution of Biotechnology to
the Spanish economy
Contribution to
GDP 2010 (%)
1,2
GDP Contribution
Employment
Macroeconomic impact of biotechnology
OECD prediction
GDP 2030 (%)
2,7
Contribution to GDP (%)
Predicted contribution to GDP (%)
Employment
Predicted employment
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 4 (07/02/2013)
Una manera de hacer Europa

5. Classification of Bio-companies
Agriculture
Food Animal Health
Environment Human Health
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 5 (07/02/2013)
Una manera de hacer Europa

6. Profile of the Biotechnology enterprise (EB) in
Spain
• Between 10 and 20 employees
• Over 80% of the staff university graduates
• Over 25% of the staff devoted to R&D
• Less than 5 years of activity
• Located mostly in Madrid, Barcelona, Andalucía, País Vasco and Valencia
• Linked to prestigious public research institutions
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 6 (07/02/2013)
Una manera de hacer Europa

7. Spain: eight Bioregions
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 7 (07/02/2013)
Una manera de hacer Europa

8. The Spanish Biotech sector :
scientific production (00-08)
Source: Genoma España
European contribution to world scientific production European contribution to world scientific
in biosciences (2000) production in biosciences (2008)
United Kingdom Germany
Germany United Kingdom
France France
Italy Italy
Netherlands Spain
Spain Netherlands
Sweden Sweden
Belgium Denmark
Denmark Belgium
Finland Austria
Austria Finland
Ireland Portugal
Portugal Ireland
Greece Greece
Luxembourg Luxembourg
UNIÓN EUROPEA
Growth: 47% (annual rate 6%)
Fondo Europeo de
Desarrollo Regional (FEDER) 8 (07/02/2013)
Una manera de hacer Europa

9. The Biotech sector in Spain:
evolution of the nº of enterprises (00-08)
Source: Genoma España
Evolution of EB and EIB
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 9 (07/02/2013)
Una manera de hacer Europa

10. The biotech sector in Spain: total
public expenditures on R&D&I biotech
Source: Genoma España
Total public support for R&D&I in Biotechnology (Mio €)
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 10 (07/02/2013)
Una manera de hacer Europa

11. Success stories
- 2000: Pfizer invested 12m euros in its European Biometric Centre, which has
support functions for the rest of Europe and USA.
- 2002: Abengoa signed a 35.5million dollar R&D Agreement with the US
Department of Energy.
- 2002: Lilly opened its research centre for medicinal chemistry, one of the
biggest in the world, investing 20 million euros.
- 2003: Serono concentrates its global growth-hormone production in Spain.
- 2005: GSK opens its research centre for tropical diseases in Spain.
- 2009: Genzyme sets up a sales office in Madrid and has a warehouse for
domestic distribution.
- 2011: Celgene opens its first research centre outside the USA in Seville. The
Celgene Institute of Translational Research Europe (CITRE) plans to focus on
advanced therapies and regenerative medicine.
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 11 (07/02/2013)
Una manera de hacer Europa

12. Spanish Technology Platforms
• Biotech Markets
• Nanomedicine www.nanomedspain.net/
• Innovative Medicines www.medicamentos-
innovadores.org/
• Plants Biotechnology www.invigen.org
• Animal Health www.vetmasi.es
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 12 (07/02/2013)
Una manera de hacer Europa

13. CDTI DATA 2011
RTD Project Nr .of funded CDTI funding Total
and NEOTEC companies investment
92 M€48,116 M€ 64,6
INNPRONTA Nr. of funded CDTI funding Total
call companies investment
(2 Projects) 17 M€ 27,67 M€ 32,56
Indo-Spanish Nr. of proposals Selected
call CDTI-DBT projects
First call 2012 7 3
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 13 (07/02/2013)
Una manera de hacer Europa

14. Potential areas for cooperation
SPANISH TECHNOLOGICAL STRENGTHS
Health and Nano biotechnology
Some Developments in 2011
• Oncology,: Advancell, GP Pharm, Ingenasa, Pharmamar, IUCT, Lipopharma, Entrechem,
Orizon Genomics
• Cardiology/ Neurological: Neuron Pharma, Sanifit,
• Oftalmology: Sylentis, Proretina Therapeutics, Biotechnology Institute, Bioftalmic
• Vaccines: Archivel Farma, Ferrer, Rovi, Leti
• Biotech diagnosis, biomarkers, nanomedicine: Orizon Genomics, Sistemas Genomicos, AB
BIOTICs, Genomica, Biobide, Pangaea Biotech, Genetadi Botech, Aromics, Nanotherapy,
Nanoinmunotech…
• Animal Health: Bionaturis, Ingenasa
• Bioinformatic: Integromics, Noray Bio, Biomol Informatics
• Regenerative medicine, Cell and Gene therapy: Tigenics (former Cellerix)
• Biofuels: Abengoa, Repsol
4th Nano biotechnology Scientific production in the world
• Barcelona the 2nd Nano biotech city (1st Boston)
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 14 (07/02/2013)
Una manera de hacer Europa

15. Institutions supporting the sector in Spain:
Promoting value creation through knowledge
www.asebio.com
• ASEBIO is the Spanish Asociation of Biocompanies
• ASEBIO belongs to and is supported by EUROPABIO, and is a part of CEOE
and SEBBM
UNIÓN EUROPEA
Fondo Europeo de
Desarrollo Regional (FEDER) 15 (07/02/2013)
Una manera de hacer Europa